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To make a large profit; to win by a large margin, or to win a large amount, especially in gambling. Also clean house.

The investors cleaned up when the stock hit the roof last year.

Additional definitions for 'clean up':

clean upTo become clean, handsome, smart in appearance, e.g. for a special occasion, especially when it is out of character to be seen as such.
clean upTo make an area or a thing clean; to pick up a mess; to tidy.
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"clean up." Phrases.net. STANDS4 LLC, 2017. Web. 20 Nov. 2017. <http://www.phrases.net/phrase/clean-up_2926>.

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