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To leave; to begin a journey or trip.

He set off in search of better opportunities.

Additional definitions for 'set off':

set offTo begin; to cause; to initiate.
set offTo cause to explode.
set offTo count an addition in one thing against a reduction in something else.
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"set off." STANDS4 LLC, 2018. Web. 19 Sep. 2018. <>.

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