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Facing; challenging, or opposing.

If you try to change the school schedule like that, you'll be up against legions of angry parents.

Additional definitions for 'up against':

up againstIn contact with, abutting.
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"up against." Phrases.net. STANDS4 LLC, 2017. Web. 19 Nov. 2017. <http://www.phrases.net/phrase/up-against_7808>.

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