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to give up, to quit

January 1989, American Motorcyclist
I rode 700 miles one day before packing it in for the night, yet after 15 minutes of rest in my hotel room, I realized that I could have gone farther.

6 Febraury 2009, Yahoo! News - At Dem retreat, a partisan love fest
As the Senate deliberated in Washington - and packed it in for the night without finalizing a deal - Obama brushed pressed House Democrats to finalize

7 November 2009, The Sun - Captain Crunch compares 'greener' light bulbs
LAST year I was diagnosed with cervical cancer and had to pack in my job as a full-time cleaner as I needed chemo and radiotherapy

Additional definitions for 'pack in':

pack into include (especially of a large amount)
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"pack in." Phrases.net. STANDS4 LLC, 2017. Web. 24 Nov. 2017. <http://www.phrases.net/phrase/pack-in_14089>.

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