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To exhaust; wear out; weary; beat; tire out; to fatigue until unable to do more.

Additional definitions for 'knock up':

knock upTo impregnate, especially out of wedlock. See knocked up.
knock upTo put together, fabricate, or assemble, particularly if done hastily or temporarily. See also knock together.
knock upIn the morning as by knocking at the door; rouse; call; summon; also, to go door-to-door on election day to persuade a candidate's supporters to go to the polling station and vote. See also knocker up.
knock upTo become exhausted or worn out; to fail of strength; to become wearied, as with labor; to give out.
knock upTo gently hit the ball back and forth before a tennis match, as practice or warm-up, and to gauge the state of the playing surface, lighting, etc. See knock-up.
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"knock up." Phrases.net. STANDS4 LLC, 2017. Web. 20 Nov. 2017. <http://www.phrases.net/phrase/knock-up_853>.

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