To take a risk.
He doesn't want to go out on a limb, but he really should give it a try sometime.
Additional definitions for 'go out on a limb':
|go out on a limb||To hazard a guess.|
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"go out on a limb." Phrases.net. STANDS4 LLC, 2018. Web. 24 Feb. 2018. <http://www.phrases.net/phrase/go-out-on-a-limb_4082>.