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To begin to feel the effects of a recreational drug.

I could tell from her expression she was coming up already.

Additional definitions for 'come up':

come upTo come to a higher position.
come upTo appear before a judge or court.
come upTo come towards, to approach.
come upTo emerge or become known, especially unexpectedly; to come to attention, present itself.
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"come up." STANDS4 LLC, 2018. Web. 20 Mar. 2018. <>.

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